Creative Destruction Lab

Deep Genomics is at the forefront of AI-powered drug development, focusing on programming RNA therapies for any gene and genetic condition. Their proprietary AI Platform identifies novel targets and evaluates therapeutic candidates, revolutionizing the approach to drug discovery.

Blue J Legal provides AI-powered tax research solutions designed to enhance the accuracy and efficiency of tax-related inquiries and decisions.

Nymi provides passwordless multi-factor authentication solutions for deskless workers, focusing on secure identity through innovative wearable technology.

Cohesic is focused on bringing decision intelligence to cardiovascular care, providing solutions that enhance the value of diagnostic tests and support clinical decisions.

Buildkite is a configurable orchestration engine designed for continuous integration (CI) that provides teams with the speed to ship software at scale. It focuses on clarity, reliability, and autonomy in CI workflows.

4D Surgical is focused on the next generation of image-guided surgery, leveraging advanced technologies to enhance surgical precision and outcomes.

Atomwise uses machine learning to discover novel, drug-like molecules for drug development, focusing on immune and inflammatory diseases.

Beam Medical is a medical device design and manufacturing firm, specialized in minimally invasive solutions to treat chronic low back pain.

BioForm Solutions is a San Diego-based contract research organization providing services for the analysis of probiotics and other microbial-based products for the supplement, food and beverage, and agriculture markets. They offer industry leading flow cytometry assays for accurate enumeration of probiotic samples.

Blue Ocean Gear provides innovative technology solutions for ocean-based businesses, focusing on real-time tracking and monitoring of fishing gear through their Smart Buoy system.

Independent VC using an aerospace systems lens to back dual-use deep-science technologies (quantum, hydrogen, climate, materials, space), prioritizing founders with outstanding technical leadership and first-principles engineering expertise.

Early-stage investor in deep-tech—AI, cybersecurity, quantum, robotics, space tech, synthetic biology—with rare bioengineering focus and technically deep partners who engage with complex product and R&D.

Early institutional backer that sources tech from academia and government labs, partnering with scientist- and engineer-led teams to deeply interrogate science, dual-use/defense opportunities, and amplify through an in-house media platform. Explicitly aims to "turn science fiction into science fact" by backing companies at the intersection of the new and the not-yet-imagined, built around scientists, engineers, and polymaths rather than traditional finance backgrounds who can deeply interrogate emerging science and complex tech. The firm systematically mines academia and government labs for "technological gems" and has become one of the earliest institutional backers of dual-use and defense technology.

Solo GP Josh Buckley—former teenage founder and Product Hunt CEO—makes concentrated, conviction-driven bets, leveraging a lean team that moves with angel-like speed and can lead sizable rounds.

Targets companies applying modern computation (AI, simulation) to agriculture, mining, manufacturing, health and defense, leveraging partners's hard-science and national-security expertise to navigate regulation and dual-use challenges.