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Define Ventures

San Francisco, California · Invests in US · Website

Pre-SeedSeedSeries AB2B SaaSAI & Machine LearningData & AnalyticsHealthcare & BiotechHardware & DevicesHealthcare & Digital HealthEnterprise SoftwareBiotech & Life Sciences

Thesis

Healthcare's future will be defined by the convergence of technology innovation, consumer preferences, and industry transformation. We partner with entrepreneurs who combine deep healthcare domain expertise with technical excellence to build category-defining companies.

Likely not a fit for

We do not invest in non-healthcare sectors. We focus on founders with both healthcare understanding and technical capability.

How they invest

Lead or follow
Usually leads
Typical decision
~2 weeks
Warm intro
Not required
Involvement
Takes a board seat
Fund status
Actively deploying
Assets under mgmt
$800M
Decision process
Partnership vote

Partners & team

9 contacts on file

CS

Chirag Shah

PartnerPartner · Primary contact

+ Pitch

c•••@de•••.com

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MW

Michael Wert

PartnerPartner

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m•••@de•••.com

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LC

Lynne Chou O'Keefe

General PartnerFounder & Managing Partner

+ Pitch

l•••@de•••.com

LinkedIn profile

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BB

Bruce Broussard

Venture PartnerVenture Partner

+ Pitch

b•••@de•••.com

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FW

Frank Williams

Venture PartnerVenture Partner

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f•••@de•••.com

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CM

Carolyn Magill

Venture PartnerVenture Partner

+ Pitch

c•••@de•••.com

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HT

Hong Truong

PrincipalPrincipal

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h•••@de•••.com

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CE

Chuka Esiobu

PrincipalPrincipal

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c•••@de•••.com

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GH

Garrett Howard

AssociateSenior Associate

+ Pitch

g•••@de•••.com

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Portfolio

Hims & HersHealthcare Digital

Hims & Hers is a telehealth company that provides personalized healthcare solutions, connecting users with licensed medical providers for a range of services including sexual health, skin care, mental health, weight loss, and hair regrowth. The platform emphasizes a customer-centric approach, allowing users to receive tailored treatment plans and 24/7 access to their Care Team through mobile apps.

Unite UsHealthcare Digital

Unite Us is a technology company focused on connecting communities, data, and care to eliminate healthcare silos and improve access to social care resources.

Cohere HealthHealthcare Digital

Cohere Health’s clinical intelligence platform and agentic AI-powered solutions connect health plans’ strategic goals and providers’ needs, optimizing the speed, cost, and quality of care.

Folx HealthHealthcare Digital

FOLX Health provides holistic healthcare and wellness services tailored for the LGBTQIA+ community, including mental health care, therapy, gender-affirming care, primary care, sexual and reproductive health, and fertility services.

CentivoHealthcare Digital

Centivo is an innovative health plan for self-funded employers founded on the belief that everyone deserves quality care at a price they can afford.

Blackbird HealthHealthcare Digital

Blackbird Health provides virtual and in-person mental health care for children, teens, and young adults, focusing on developmental differences, mental health concerns, and behavioral issues.

TiaEnterprise Software

TIA innovations GmbH develops software solutions for customs, foreign trade, and compliance for over 40 years.

FoundFintech Payments

Found is a financial technology company offering business banking services for small businesses, including expense tracking, tax savings, and secure banking solutions.

Story Health
Layer HealthHealthcare Digital

Layer Health is a healthcare AI company that has developed an enterprise LLM platform for scalable and efficient medical chart review, utilizing AI to enhance clinical decision-making and improve patient care.

HyroHealthcare Digital

Hyro provides conversational AI solutions tailored for the healthcare sector, enabling organizations to automate repetitive tasks, enhance patient engagement, and gather actionable insights from interactions.

Solara Health

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Research briefRead more
Define Ventures Research Executive Summary Define Ventures is one of the largest venture capital firms exclusively focused on early-stage digital health companies. Founded by Lynne Chou O'Keefe, the firm manages $800 million in assets under management across six funds and has established itself as a category-defining investor in healthcare technology. The firm combines deep healthcare expertise wi

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