Fifty Years

Upside Foods is a pioneer in cultivated meat, offering delicious chicken products grown directly from animal cells, aiming to provide a more humane and sustainable alternative to traditional meat production.

Solugen is redefining chemical manufacturing by harnessing the power of biology and chemistry to create sustainable chemical solutions for various industries, including oil and gas, renewable fuels, and agriculture.

BillionToOne is a molecular diagnostics company focused on creating accessible prenatal screening and liquid biopsy tests.

Athelas is an AI-driven platform designed to enhance healthcare operations for modern medical practices. By integrating solutions like revenue cycle management (RCM), electronic health records (EHR), and ambient AI, Athelas aims to simplify healthcare processes, reduce administrative burdens, and improve financial outcomes for providers.

Astranis builds the world's most advanced satellites for high orbits, focusing on dedicated satellite broadband and supporting government science, PNT, and communications missions.

Substack is a new media app that connects you with the creators, ideas, and communities you care about most. It allows writers and creators to publish their work and monetize it through paid subscriptions, fostering a direct relationship between creators and their audience.

Varda Space Industries is industrializing low Earth orbit by processing materials in microgravity and returning them to Earth, focusing on biopharma and other industries.

Worldcoin is a digital identity and financial network designed to provide universal proof of humanity, enabling secure access to services and financial systems for real humans, while distinguishing them from AI.

BioRender is the world’s first tool to help scientists create and share beautiful, professional scientific figures. It provides a platform for creating custom science visuals quickly and easily, utilizing AI tools to enhance the design process.

New Therapies for Lung Cancer & Beyond, targeting undruggable transcription factors.

Catalog DNA is pioneering the use of synthetic DNA for data storage and computing, aiming to revolutionize the economics of data management by leveraging the ultra-dense and stable characteristics of DNA.

Invests in disruptive, technology-focused startups; established in 1999.

Invests at seed and early stages in purpose-driven, trailblazing entrepreneurs with unique ideas capable of reinventing entire industries. Focuses on companies founded by mission-driven founders building transformative technologies.

An aggressive techno-optimist investor that tolerates ~70% failure to back capital-intensive, science-heavy climate, healthcare and deep-tech bets, embracing extreme technical risk and non-consensus opportunities. Led by Sun Microsystems founder Vinod Khosla, the firm explicitly optimizes for black swan outcomes and actively seeks opportunities that appear crazy to most of the market through non-consensus thinking.

Extremely concentrated, multi-decade investor in capital-intensive physical-world tech (rockets, BCI, nuclear micro-reactors) offering long-term support and unusually deep access to Elon Musk ventures; invested $1B+ in SpaceX.