Wireframe Ventures

Enveda Biosciences is a biotech company leveraging AI to discover and develop drugs from natural compounds, focusing on translating nature's chemistry into effective medications.

Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop potential long-term curative therapies for patients with life-threatening and debilitating diseases.

Xcimer is building the world’s biggest, brightest and most powerful lasers to commercialize the only scientifically validated form of fusion energy on Earth. Founded in 2022, Xcimer aims to deliver electricity through laser fusion technology, which has the potential to power various energy-intensive sectors.

LevelTen Energy accelerates the clean energy transition by facilitating frictionless renewable transactions through its marketplace platform.

MycoWorks is a biotechnology company that specializes in creating sustainable materials from mycelium, a natural and abundant resource. Their flagship product, Reishi™, is engineered using Fine Mycelium™, offering a premium alternative to traditional animal leathers.

SPAN® offers smart electrical panels and EV charging solutions that integrate with home energy systems, enabling efficient energy management and electrification.

Near Space Labs specializes in providing high-resolution aerial imagery and data analytics using advanced balloon technology to capture images from the near-space environment.

Recurrent analyzes millions of real-world miles each week to give you the information you need to buy, sell, and understand electric vehicles with confidence. Our battery scientists study dozens of datapoints like temperature, age, and charging patterns to create simple, visual insights that make it easy to find the right new or used electric vehicle.

Full Harvest is the leading B2B marketplace for USDA Grade 1, surplus, and imperfect produce, connecting growers with commercial buyers to reduce food waste and improve the efficiency of the produce supply chain.

Astronomer provides a fully-managed data operations platform powered by Apache Airflow, enabling organizations to streamline their data workflows and enhance data observability.

Palantir builds platforms for integrating, managing, and securing data, enabling human-driven analysis of real-world data. Their products are designed to empower users to ask complex questions without needing advanced technical skills.

Reverie Labs places computation, chemistry, and creativity at the center of drug discovery. It uses innovative computational chemistry and machine learning tools to accelerate its drug discovery programs, focusing on developing kinase inhibitors to address unmet patient needs.

Refactor Capital is a solo GP venture fund where founders get direct access to Zal Bilimoria as the only decision-maker, applying software operator experience from Google, Netflix, and LinkedIn to hard tech sectors like aerospace, synthetic biology, and energy storage. The fund leads seed rounds with $1-2M checks targeting ~10% ownership across unusually broad hard-tech domains, backed by early hits like Solugen and Astranis.

Early-stage, first-money-in partner for technically ambitious founders transforming the physical world (energy, defense, infrastructure, space, advanced manufacturing), underwriting high technical and regulatory risk.

Backs mission-driven founders leveraging science and technology to achieve the UN Sustainable Development Goals.

Invests in disruptive, technology-focused startups; established in 1999.